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The overall structure of mTORC1 and its interactions with RHEB and RAGRagulator are consistent with previous structures determined in the absence of membranes 4,14,15,19,20 , including the large conformational change induced by RHEB binding 4

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First-line treatment with infliximab versus conventional treatment in children with newly diagnosed moderate-to-severe Crohns disease: An open-label multicentre randomised controlled trial