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NAD + is also involved in nucleotide and amino acid synthesis, such as the folate-dependent serine catabolism 347 , as well as genomic DNA replication, as reviewed above 118

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Most reported side effects of these peptides in studied doses are mild (injection-site irritation, transient sleep or vivid dreams, headaches), but longterm, largescale human safety dataespecially for longevity useremain limited