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In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al

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These findings suggest BPC-157 may modulate neuroinflammation and promote neural tissue preservation through mechanisms consistent with its known cytoprotective activity in other tissue types

FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 34 (2), 32893304