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6 Limitation and future research priorities Despite the promising potential of ferroptosis-targeting therapies, several limitations currently hinder their translation into clinical practice

Iron metabolism is disturbed and anti-copper treatment improves but does not normalize iron metabolism in Wilsons disease

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In parallel, microglia mediate the engulfment of supernumerary synapses during postnatal development, revealing an immune [microglia-specific complement receptor 3 (CR3)/C3 signaling]-driven mechanism for sculpting neural circuits (Stevens et al., 2007