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Kisspeptin can induce ovulation by initiating GnRH release, and synthetic kisspeptin is being tried to timely trigger ovulation with less ovarian hyperstimulation risk

[DOI] [PubMed] [Google Scholar] 90.Gibney EJ

Bone Spine 89 , 105402 (2022)

With this in mind, the resistance of small molecule agonists or antagonists appears due to reduction of the binding affinity by mutation of target, PROTAC is likely to overcome this challenge

this is associated with thinning of the fibrous cap leading to decreased stability of atherosclerotic plaques and an increased risk of plaque rupture [49]

Understanding these markers may help readers appreciate their advantages in non-invasive diagnostic applications