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In some embodiments, the otoprotectant is a compound of Formula (VIII): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

Oral supplementation of this formula will have beneficial effects on the extracellular matrix of the skin, which will help reduce cellulite

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Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nunez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Sustained receptor engagement allows continuous activation of satiety pathways without repeated peaks and troughs

Lyophilized peptide refrigeration duration Lyophilized peptides in sealed vials represent the most stable storage configuration