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"Selenium and human health." Lancet

So free radicals, heavy metals, and environmental toxins stick to it

War AR, Taggar GK, Hussain B, Taggar MS, Nair RM, Sharma HC

Author contributions AE, AK, GG, and LK conceived the idea and wrote the manuscript

Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)

H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)