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In an experimental model, transgenic mice expressing a kinase-deficient IGF-1R -subunit (thus displaying reduced signal transduction in both IGF-1R and hybrid receptors) developed diabetes early on life [162, 236]

PMID 25875118

History of serious hypersensitivity reaction (anaphylaxis, angioedema) to GLP-1 receptor agonists

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It's also important to be aware of the risks associated with a low-calorie diet, which may be part of your program