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DiscoTope-3.0, on the other hand, accurately predicts discontinuous B-cell epitopes using inverse folding from solved or AlphaFold structures, outperforming current methods on both linear and non-linear epitopes

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P-glycoprotein (P-gp, ABCB1) increases in many gemcitabine-resistant cell lines and pancreatic cancer samples, and molecular docking plus lab tests show it can bind and pump out gemcitabine

Important considerations include: neither peptide has received broad regulatory approval for routine therapeutic use in major jurisdictions

Tirzepatide is the symbol of the status quo, while retatrutide is the symbol of the near future