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When a compound is ingested orally, it goes through the digestive system and is processed by the liver before it ever reaches the rest of the body

Biochim Biophys Acta 1797(67):11631170 Kovac S, Domijan A-M, Walker MC et al (2012) Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death [J]

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10.1038/s41575-018-0061-2 Summary Keywords Glucoraphanin, gut microbiota, Nrf2, oxidative stress, sulforaphane Citation Dmytriv TR, Lushchak O and Lushchak VI (2025) Glucoraphanin conversion into sulforaphane and related compounds by gut microbiota

Martchenko, S