In a study on HCC, we were pleasantly surprised to find that the HGF/c-MET pathway and FGF19/FGFR4 collaboratively enhance ETV4 expression in HCC cells via the ERK1/2 axis, where ETV4, an ETS transcription factor upregulated in all HCC stages, increases PD-L1 and CCL2 expression, resulting in MDSCs and TAMs infiltration, CD8 T cells suppression and HCC metastasis [79, 80]
doi: 10.1016/j.vetpar.2023.110011 32 Witko-SarsatVNguyen-KhoaTJungersPDrekeTBDescamps-LatschaB
Nat Rev Immunol 11 , 264274 (2011)
It may also help lower cholesterol levels, fight symptoms of fishy odor syndrome, improve kidney function, and reduce gas and diarrhea
10.3390/antiox10081198 132
References Wade J, Byrne DJ, Ballentine CJ, Drakesmith H