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Excess Th1 compared with Th2 for prolonged periods of time, in the absence of acute infection, is known as Th1 dominance and is associated with tissue specific autoimmune diseases such as Hashimotos

Mol Cell Biochem 254(12):227234

At a time when catalase was the best-known H 2 O 2 -removing enzyme in plants, the paper emphasised the integration of ROS removal with NADPH-producing metabolism

This initiates the extrinsic pathway and further amplifies mitochondrial damage through BH3 interacting domain death agonist (BID) cleavage, linking both pathways at the mitochondrial level (Stergiou and Hengartner 2004)