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Since it is hard to obtain clinical samples in overdose cases that control the many genetic and environmental variables that can affect protein expression, it is often easier to discover proteomics biomarkers in nonclinical toxicity studies and then set up clinical sample collection strategies to further evaluate the potential toxicity biomarkers

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here, the variant forms of the gene may lead to altered transcription of the gene such that the final protein is expressed in abnormal amounts (compared with the amounts produced by individuals carrying the more common, or wild-type, allele)

2014 Jul 23-30;312(4):380-9

275 Targeting HSP70 HSP70 targeting has yielded several mechanistically distinct anticancer strategies

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