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Borner T, Geisler CE, Fortin SM, Cosgrove R, Alsina-Fernandez J, Dogra M, Doebley S, Sanchez-Navarro MJ, Leon RM, Gaisinsky J, et al

& Berson, S

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showed that p53 could indirectly trigger arachidonate 12-lipoxygenase (ALOX12) function through transcriptional inhibition of SLC7A11, thus leading to ALOX12-dependent ferroptosis resulting from ROS stress ( Cells have several death escape mechanisms