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The variability suggests individual factors heavily influence this outcome

In the past, when oral contraceptives contained relatively high amounts of estrogens, studies estimated the relative risk for hepatic adenomas as 2.5 times greater for women who had taken oral contraceptive pills for 3 to 5 years compared with women who had taken them for 1 year or less

Sikric P, Seiwerth S, Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications

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Unlike direct hormone replacement, it encourages the body to maintain its own regulatory feedback systems