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Do not administration by the intravenous route

The sample size was determined by reference to a previous report [17]

Without adequate copper, newly synthesized collagen remains weak

Funding This work was supported by the Projects of Medicine and Health Science Technology Development Program in Shandong Province [2016WS0499], Shandong Provincial Natural Science Foundation of China Grants [ZR2019PH025]

All cells were cultured in an endothelial cell-specific medium for human umbilical vein endothelial cells, which was supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin (PCM-H-040, ZQXZbio, China)

Treatment aims to restore normal function to the blood cells and reverse any symptoms related to the deficiency