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Regular exercise activates transcription factors (NF-B and Nrf2), which are responsible for stimulating various genes including mitochondrial GSH-GPx [102,103]

Another randomized controlled trial observed the upregulation of vitamin D receptor ( VDR ), glutathione S-transferase A3 ( GSTA3 ) and interleukin 21 receptor ( IL-21R ), as well as the downregulation of prostaglandin-endoperoxide synthase 2 ( PTGS2 ), advanced glycosylation end-product specific receptor ( AGER ) and retinoid X receptor beta ( RXRB ) in women receiving vitamin D supplementation compared to placebo (80)

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doi: 10.1165/AJRCMB.17.3.2998M 100 LiewFYLiYSevernAMillottSSchmidtJSalterMet al

PMID: 33 ZhangZYangZLinSJiangSZhouXLiJet al

doi: 10.4269/ajtmh.20-0473 223 ProalA