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These data support that TfR2 is responsible for the known efficient targeting to the liver of intravenous heme-HPX ( FIGURE 5 3.3 Isolation and identification of hemeHPX binding proteins from two models of human liver cells: pilot studies 3.3.1 Evidence for hemeHPX receptor-mediated heme transport in HepG2 cells and primary human hepatocytes using HMOX1 induction by hemeHPX Several published studies on the HPX system/network with primary cells, e.g