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4-Hydroxynonenal is involved in the signaling of cell proliferation and apoptosis, as well as regulating gene expression in different cell types (Yang et al., 2001

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This conclusion requires validation in future studies with a larger sample size

Sections were stained with hematoxylin and eosin for histological analysis and the slides were examined under a Keyence BZ-8100 microscope (Keyence Japan, Osaka, Japan)

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