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Conventional antiresorptive agents such as zoledronic acid, have also been reported to promote osteoclast ferroptosis in preclinical models

Repeated attempts to engineer an enzymatically dead kinase via a D135A mutation were unsuccessful, strongly suggesting that this kinase and its enzymatic activity are vital for animal viability

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World malaria report 2021

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doi: 10.1186/s12885-019-5642-0