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There are major differences between cellular and extracellular compartments in concentration of the thiol/disulfide systems and the relative redox states

In apoptotic or necrotic human melanoma cells, peroxide levels can rise to more than 500 M (Figure 3)

Evaluation of the total amount of SOD gives an overview of the overall SOD detoxifying capacity of the studied system

J Clin Endocrinol Metab (2002) 87:48999

Intratumoral administration of CD1c (BDCA-1)(+) and CD141 (BDCA-3)(+) myeloid dendritic cells in combination with talimogene laherparepvec in immune checkpoint blockade refractory advanced melanoma patients: a phase I clinical trial