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[52] The adolescent brain seems to be particularly sensitive to neuroplasticity as a result of nicotine

Notably, while the 2D model primarily exhibited oxidative stress-associated signatures (SBS3, SBS5 and SBS18), the organoid system showed a shift toward the smoking-related SBS4 signature

Heterogeneity among the included studies prevented conducting a systematic review and meta-analysis, leading the authors to conduct a scoping review

(2024) 16:e54051

Airways hyperresponsiveness, bronchodilator response, allergy and smoking predict improvement in FEV1 during long-term inhaled corticosteroid treatment