Compounds to Avoid DSIP should not be combined with sedative medications, benzodiazepines, or other CNS depressants without medical supervision

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For instance, sour tea (2040 mg/kg) taken with hydrochlorothiazides (10 mg/kg) significantly increased urine volume in rats, raising the risk of dehydration (667)
In this sense, it is worthy of note that several BZ delivery platforms and formulations are been assayed in pre-clinical studies (Scalise et al., 2016
The evidence for APE1 in ALS is therefore somewhat conflicting