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A progestin-releasing IUD differs from a copper IUD in that it has a reservoir of the synthetic hormone levonorgestrel (LNG) that is slowly released inside the uterus

Thats exactly why so many in-vitro experiments use fibroblast cultures as their starting point when studying this compound

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USA 101 , 33813386 (2004)

Findings remain preliminary, and further investigation is required to clarify their roles

While the precise mechanism underlying this hierarchical chemoattractant-induced PTEN redistribution remains unclear, it is likely to contribute to reduced PIP3 levels at the leading edge, thereby promoting neutrophil migration toward PI3K-independent chemoattractants