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Nrf2s functional coordination is achieved through its domains: C-terminal Neh1 and Neh3 mediate DNA binding and transactivation, respectively, while N-terminal Neh2 enables Keap1-dependent negative regulation via its ETGE and DLG motifs (69, 70)

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It reduces inflammatory cytokines, promotes Treg function, and exhibits antioxidant effects that protect tissues from inflammatory damage

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils