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Glutathione in particular has very low oral bioavailability versus near-complete IV bioavailability

Chem Biol Interact 2006

However, the exact role of GST enzymes in the mechanism of ISR is still far from elucidated because transgenic plants overexpressing or suppressing the symbiont-inducible GSTs have been rarely studied (Kao et al., Conclusions and Future Perspectives Since the beginning of plant GST research in 1970 the fundamental questions have remained largely unanswered: what are the physiological roles of GST isoenzymes and which metabolites are the natural, endogenous substrates of GSTs

DOI: 10.1038/s41598-017-03776-9 50

precuneus, posterior cingulate and occipital ROIs) or increases (N = 2, medial frontal and sensorimotor ROIs) in old adults

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