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However, a study indicated that inhibition of the HGF/c-MET pathway can improve the sensitivity of CRC to EGFR inhibitors, indicating that combination therapy could still be a future research direction ( Currently, relatively few reports about HGF inhibitors in CRC exist

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H.LahusenT.XuX.VassilopoulosA.et al (2010)

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This approach wastes product without improving results

We therefore studied the expression of enzymes involved in cell defense mechanisms