SAM is involved in hundreds of methylation reactions throughout the body, and the systemic effects of preserving SAM through NNMT inhibition in tissues beyond adipose tissue remain unknown
Neither compound holds MHRA or EMA marketing authorisation
This timeframe allows assessment of individual response, opportunity to adjust dosing, and generation of meaningful results without committing to an extended protocol
Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity
A 500mcg daily protocol under split dosing would look like: 300mcg upon waking (fasted), then 200mcg approximately 30 minutes before dinner or before bed on an empty stomach
Administering near target fat areas Some protocols suggest administering AOD-9604 near areas of stubborn fat with the theory that local administration may enhance local effect