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Concurrently, the review places a special emphasis on the clinical validation status of the selected combinations, including at the expense of discussing the most prevalent pharmacokinetic problems, formulation issues, and patient safety concerns

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However, despite their significant therapeutic potential in cancer treatment, it is essential to also focus on managing immune-related adverse events (irAEs)

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Taken together, our observations indicate that HNF4, SAA metabolism genes, and SAA metabolism are positively linked in human liver tumors and cell lines, and that SAA metabolism is altered in HNF4-negative mesenchymal liver cancer cell lines