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Many patients experience significant improvement in symptoms within days of the first shot

S., Wilms, E

Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues

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GSH functions as a cofactor for GPX4, an enzyme that protects cell membranes from oxidative damage by converting lipid peroxides into less harmful lipid alcohols (34)