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To secure identifiability, the disposition model (including fixed-effects parameter values and variance of random-effects parameters) was a fixed component in the current model

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Balancing the Walsh Protocol with Folinic Acid Therapy in Autism The Walsh Protocol typically avoids folate supplementation in individuals with autism because most autistic individuals are undermethylators, a condition characterized by low serotonin activity and high SERT (serotonin transporter) expression, leading to excessive serotonin clearance

doi: 10.1097/00005344-199410000-00016 53 IsaacCMathorMBBarianiGPaggiaroAOHersonMRGoldenstein-SchainbergCet al

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