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Androgens have been shown to downregulate the expression of bile-salt export pump (BSEP) and multidrug resistanceassociated proteins (MRPs), resulting in bile-acid retention and cytotoxic accumulation within hepatocytes

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It is a progressive biological renovation better hydration in the first two weeks, visible texture refinement by weeks 34, measurable firming and wrinkle reduction by weeks 812, and a genuinely younger-looking dermis by week 20

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Journal of the American Society of Nephrology 21 , 12991308, doi: 10.1681/asn.2009070722 (2010)