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On the other hand, both in animal models and in patients, DM2 is frequently accompanied by islet fibrosis

Translating animal doses to human equivalents requires consideration of species-specific pharmacokinetic differences

Specifically, COX26 , a structural subunit of cytochrome c oxidase (complex IV) 20 , and ATP19 , a component of the FF-ATP synthase (complex V) 21 , were both significantly downregulated following thiolutin treatment (Fig