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Useful anti-aggregation additives include, by way of example only, urea, guanidinium chloride, simple amino acids such as glycine or arginine, sugars, polyalcohols, polysorbates, polymers such as polyethylene glycol and dextrans, alkyl saccharides, such as alkyl glycoside, and surfactants

10.3233/JAD-140396 446 TarangeloA.RodencalJ.KimJ

The mitogen-activated protein kinases (MAPKs) family, including extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun NH2-terminal kinase (JNK1/2), has been shown to play a significant role in the mediation of signals triggered by cytokines, growth factors, and environmental stress and is involved in various cellular functions [9, 10]

Indeed, in 23 patients out of a total of 25, 5-MTHF in CSF was low despite normal serum folate treatment with folinic acid for a year restored folate levels and led to clinical improvements