Its efficacy is demonstrated through the reduction of liver fat, improvement of liver function markers, and regulation of specific genes such as Atf3 and Acox2, supporting its development as a targeted therapy (82)
In biochemical and preclinical models, the peptide appears to regulate endothelial activity, cell migration, and cytoskeletal organization through interactions with kinase signaling cascades and nitric oxide related mechanisms
(2026) Figures were prepared using Affinity Designer 2.6.0 (Serif) and GraphPad Prism v10.5.0 (GraphPad Software, San Diego, CA, USA)
CT Methods 25 , 402408 (2001)
Their mechanisms of action are summarized in Figure 3 , and the classification, molecular targets, and known resistance mechanisms are listed in Table 1
MM: Conceptualization, Methodology, Writing original draft