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Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, debilitating disease characterised by a wide range of symptoms that severely impact all aspects of life

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346 Furthermore, CRISPR-Cas interventions may induce unintended genomic alterations, including small insertions/deletions and structural variations such as translocations, inversions, and large deletions, posing risks to patients

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While some discrepancies remain, most notably opposing findings on the size of IPSC reduction after Aldh1a1 knockout (Kim et al., 2015