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The detoxification process mediated by GSTs is a fundamental mechanism that safeguards cellular integrity against environmental pollutants, therapeutic drugs, and damaging products of oxidative stress, highlighting their indispensable contribution to overall physiological well-being

Lancet Oncol 24:12061218

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There is a second pathway that breaks down levodopa, via the enzyme catechol-O-methyltransferase (COMT)

HDAC6 inhibitors such as tubastatin A and the clinically approved ACY-1215 (rocilinostat) enhance aggresome formation and autophagic clearance, reducing tau and -synuclein aggregates in AD and PD models

& Newatia, A