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Disruption of redox coupling can be seen in experimental models where astrocyte-specific mutations in the superoxide dismutase gene lead to enhanced motor neuron degeneration, an effect mitigated by mitochondrial-targeted antioxidants like MitoQ ( 4 Sleep disturbances and impaired brain metabolism are closely interconnected, both contributing significantly to the aging process Sleep is an active process initiated and supported by distinct neural populations within the brain

Furthermore, combining WFA with Fer-1 reduces hemin-induced neuronal damage in SH-SY5Y cells, reinforcing the therapeutic potential of dual ferroptosis inhibition (196)

Where the evidence has limits The majority of published work is preclinical (cell-culture and animal)

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: a multi-sample network analysis study

Appl Surf Sci

Protective Effect of Nitric Oxide on Ischemic Retina