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RGN-259 treatment promoted rapid healing of corneal epithelial defects, improved Mackie classification disease stage, and produced significant improvements in ocular discomfort, foreign body sensation, and dryness, with no significant adverse effects

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PMID 28035768.

Additionally, a 60% lower mitophagy ratio and a significant increase in the accumulation of damaged mitochondria were observed in the hippocampal brain region of APP/PS1 model mice (Fang et al., 2019)