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Probably because when a person uses tobacco, either by smoking cigarettes, using chewing tobacco, or using another form of tobacco, it acts on receptors in the brain to make you feel better by stimulating the pleasure center

Germline analysis also suggests that hormones play a role in LCNS pathogenesis, as Zhang et al

Nihon Koshu Eisei Zasshi 1998, 45: 10001010

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"It's bad enough that e-cigarettes cause nicotine addiction and may be dangerous to a person's health, but now it seems they're doubling as a ticking time bomb," he said