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Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation

The details are included in B12 Supplementation Trials, but the baseline parameters were such outliers, and the response to treatment was so drastic, that the lines didnt fit in the charts

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It is normally withdrawn, mixed with the drug, and then that mixture is injected (usually intramuscularly or subcutaneously, as indicated for the drug)

doi: 10.1038/s41598-018-27395-0