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The peptide is amphiphilic, with hydrophobic residues (Trp, Ala) and acidic/polar residues (Asp, Ser, Glu) distributed along the chain

This is meaningful because insulin resistance in muscle is one of the earliest signs of metabolic dysfunction, and one of the harder things to reverse with diet alone

3 Composition of bee venom BV is a complex mixture composed primarily of water (88%) and various peptides, enzymes, and other compounds

DSIP subsequently became the focus of numerous experimental studies examining peptide structure-function relationships and signalling dynamics within controlled laboratory settings