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For years, researchers suspected it existed naturally in the human body, and in 2017, Epitalon was detected for the first time in physiological pineal gland extract, confirming it as an endogenous compound

It is a tripeptide composed of glutamate, cysteine, and glycine, with a unique gamma peptide bond between the glutamate side chain and cysteine that protects it from normal peptidase degradation

Oest, Front

The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain

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