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Downstream genes regulated by the Nrf2/ARE axis include HO-1, NQO1, and iron metabolism-related proteins (FTH1, FTL, FPN1), etc.: HO-1 degrades pro-oxidative heme to produce bilirubin with iron-chelating activity, and NQO1 directly scavenges lipid free radicals

Promotes fibroblast migration (FAK-paxillin pathway), collagen synthesis, and granulation tissue formation

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