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if HMGB1 is central, inhibition of the TLR4/NLRP3 pathway is required

The pathological hallmarks of PD include selective degeneration of dopaminergic neurons in the substantia nigra (SN) and -synuclein (-syn) aggregation, and increasing evidence implicates ferroptosisa form of iron-dependent regulated cell deathin disease progression (248)

Sterile bacteriostatic water containing 0.9% benzyl alcohol

This is likely the effect of the specific culture components

Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice

Kim HJ, Park SH, Park SY, Moon UY, Lee BD, et al: Epigallocatechin-3-gallate inhibits interleukin-1beta-induced MUC5AC gene expression and MUC5AC secretion in normal human nasal epithelial cells