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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

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Key Benefits: Dilution for Injectable Medications: Used for preparing medications requiring dilution before intravenous (IV), intramuscular (IM), or subcutaneous (SC) administration

Pyridoxine requirements are also increased during lactation