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It was noted that two patients did not respond to treatment and consequently their score was noted in negative and hence the standard deviation was found to be high

double-blind, randomized, sham-controlled study) have shown a symptomatic benefit on ataxia scores (SARA and ICARS) and quantified measurements such as the 8-m walking time and performance scores from the nine-hole peg test [215, 216]

Then part of treatment was to give steroids to quell the inflammation

A mathematical model of the folate cycle: new insights into folate homeostasis

48 children (ages ~312) were randomized to leucovorin (2 mg/kg per day, max 50 mg, split twice daily) or placebo

10.1016/j.ymthe.2017.03.024 Mol