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Nicotinamide Adenine Dinucleotide (NAD) is a coenzyme found in all living cells

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A deficiency in Vitamin B12 restricts the supply of oxygen to cells including hair cells which may result in premature greying

Within the context pf peroxisomal metabolism, CoA is required for the oxidation of very long-chain fatty acids as well as branched-chain fatty acids and the 3-methyl branched-chain fatty acid, phytanic acid

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An added factor is an increase of the hormone cortisol, which can cause the skin to become less pliable and resistant