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A randomized, placebo-controlled trial involving patients with metabolic syndrome found that supplementing with just 300 mg/day of ALA for four weeks improved flow-mediated vasodilation (FMD) by a staggering 44%

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765 In addition, caffeic acid, 766 -caryophyllene, 767 15, 16-dihydrotanshinone, 768 icariside II, 769 rehmannioside A, 770 kaempferol, 771 rhein, 772 loureirin C, 773 quercetin, 774 and kellerin 775 suppress ferroptosis induced by cerebral I/R injury by activating the Nrf2 signaling pathway, which further suggests that activating the Nrf2 signaling pathway may be a potential treatment for relieving cerebral I/R injury

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