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Older adults and people taking metformin or acid-suppressing drugs who have confirmed low levels or absorption issues (NIH ODS)

Published in vitro and animal-model research has examined NNMT inhibition in connection with several areas of scientific interest, including adipocyte metabolism, NAD pathway regulation, mitochondrial function, and cellular energy signaling

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Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)

you must maintain healthy eating habits and regular exercise to achieve and sustain weight loss